Restorative like a treatment carried out in the office, but sold in K-beauty bottles often offered for less than 25 euros: this new active ingredient is causing a sensation on TikTok and in Korean skincare routines. Serums, creams and masks with clinical packaging promise to smooth fine lines, soothe redness and give the skin that famous translucent glow. But between viral phenomenon and real effectiveness, it is difficult to know if these treatments really deserve their place in our bathrooms.
This asset is the PDRNfor polydeoxyribonucleotide, a derivative ofSalmon DNA used for several years in the field of regenerative medicine. A review published in Annals of Dermatology describes in particular its action on the adenosine A2A receptor, involved in tissue repair mechanisms.
Since 2026, PDRN has established itself in numerous formulas from K-beauty. Serums, creams or masks: products are multiplying and displaying very varied concentrations and combinations of active ingredients. Here are the ones that particularly attract attention.
Care at the PDRN which is performing well
For those who are primarily looking for an effect on firmness, the PDRN Peptide Serum from Medicube has established itself as one of the flagship products of the trend. Sold for around 17 euros, it claims 10,000 ppm of PDRN from salmon, or around 1%, in a light and non-sticky texture. It may be particularly suitable for skin looking for more suppleness and a plumper appearance.
To focus on both radiance and firmness, COSRX Intense Collagen Serum, sold for around 22 euros, combines PDRN and collagen. Dehydrated skin can turn to Anua Serum in capsules, priced around 25 euros, which combines PDRN and hyaluronic acid.
Another option: the PDRN Regenerating Cream, around 21 euros, which combines PDRN, niacinamide, collagen and hyaluronic acid in a fragrance-free gel texture.
PDRN: what benefits can we really expect?
The main interest attributed to PDRN concerns its role in tissue repair and regeneration mechanisms. Work describes in particular an action via the adenosine A2A receptor, as well as possible support for the mechanisms involved in the production of collagen.
On the skin, the objective is therefore to promote a more supple, smoother and better hydrated appearance. But we must keep in mind an essential difference: a PDRN cosmetic does not have the same action as an injectable treatment.
As noted in particular Alluretreatments applied to the skin offer more progressive effects and cannot be directly compared to PDRN injections performed in the office.
And not all formulas necessarily contain PDRN from fish. The Ordinary, for example, offers an eye contour cream with Lacto-PDRN presented as plant-based, sold for around 10 euros and tested under ophthalmological supervision.
For those who are primarily looking for a hydrating and refreshing effect, the PDRN hydrogel mask can also find its place in a routine. Used occasionally, it focuses above all on a feeling of freshness and prolonged hydration to give the skin a more rested appearance when you wake up.
How to choose PDRN treatment?
Before falling for a bottle with futuristic packaging, it is better to take a close look at the composition. The announced concentration is a first indicator : When a brand displays 10,000 ppm, this corresponds to approximately 1%.
You then have to look at the other associated assets. Hyaluronic acid, niacinamide or collagen can complete the formula and meet different needs depending on the condition of the skin.
Finally, if your skin is sensitive or reactive, it is better to choose a suitable formula and carry out a test on a small area before integrating it into the entire routine.
And above all, even with the most trendy skincare of the moment, one gesture remains essential: daily sun protectionwhich remains one of the most important reflexes to prevent skin aging and protect the skin.