On July 10, the ANSM reacted in the face of a disturbing rise of the online sale of psychoactive substances: nine Synthetic benzodiazepineswith serious or even fatal effects, have just been classified as psychotropic drugs. Here’s what you need to know to avoid the worst.
ANSM alert on highly dangerous molecules
On July 10, 2025, theNational Medicines Safety Agency and Health Products (ANSM) announced the classification of Nine summary benzodiazepines on the list of psychotropic substances. In fact, they no longer escape regulations.
In its press release, the ANSM explains that these substances “present health risks: risks of abuse, dependence and overdose “. She also specifies that “The reported side effects include severe sedation (drowsiness to coma), confusion, agitation, alteration of memory, balance and coordination disorders, and difficulties in breathing “.
Another major difficulty: these molecules are “generally used at low doses, which can make them difficult to detect in the blood “. In case of poisoning, this strongly complicates diagnosis and medical management. ANSM adds that their effects may persist “Several days after consumption, including in the absence of recent consumption “.
The 9 Benzodiazepines of synthetic prohibited
Here are the nine molecules concerned, now registered as psychotropic drugs:
- Bentazepam
- Bromonordiazepam (Disalkylgidazepam)
- Flubrotizolam
- fluclotizolam
- gidazepam
- methylclonazepam
- Norflurazepam (Norfludiazepam)
- Thionordazepam (Demethylsulazepam)
- Tofisopam (Emandaxin)
These substances are sometimes sold in the form of powder, blotters or liquid. According to the ANSM bulletin, some can “Attach to GABA-A receptors with high affinity “which would explain their powerful and prolonged effects.
Most have no marketing authorization in France. The ANSM recalls that their use exposes to a high risk of dependence and serious medical complications, especially when combined with other depressants of the central nervous system.
What to do in case of undesirable effects or suspicion of intoxication?
In the event of disturbing symptoms after a supposed or proven to take, the ANSM recommends the following reflexes:
- Immediately call the SAMU (15) If a person presents signs of extreme drowsiness, mental confusion, respiratory problems or loss of consciousness;
- Do not suddenly stop taking if you take synthetic benzodiazepines repeatedly: this “Can cause withdrawal syndrome with anxiety, insomnia, agitation, even convulsions “;
- Consult a doctor or get closer to a Pharmacodependence-Addictovigilance (CEIP-A) assessment center;
- In the event of serious side effects, carry out a report on report.social-sante.gouv.fr.
The ANSM bulletin also specifies that “If a patient presents an alteration of consciousness, hypotonia and respiratory depression without signs evocative of opioid intoxication, intoxication to benzodiazepines of synthesis must be envisaged “. In this context, the administration of Flumazénila benzodiazepine antagonist can be used as antidote and diagnostic test.