If you go a little further into the category of calcium channel blockers, all the ‘dipine’ medicines belong to the group of Dihydropyridine. This implies that many medications, including amlodipine, operate primarily on your arteries (instead of your heart cells) and reduce blood pressure efficiently.
Amlodipine is an efficient therapy for hypertension because it makes it simpler to pump blood across muscles in your arteries by acting as the active component. This reduces your heart stress and reduces the long-term dangers of hypertension.
Although hypertension is a common disease and, if left untreated, it can harm the brain, heart, blood vessels, kidneys, and other organs. Damage to these organs can result in heart disease, a heart attack, heart failure, stroke, renal failure, eyesight loss, and other complications.
How will Amlodipine work and why is it given as a prescription?
Amlodipine begins to work the day you take it, although it may take a few weeks for complete impact. If you’re taking amlodipine for high blood pressure, you might not notice any side effects.
Amlodipine is a blood pressure medication that can be used in conjunction with other drugs. Lowering blood pressure helps avoid strokes, cardiac difficulties, and kidney problems. It lowers blood pressure by enabling the heart to pump more effectively by relaxing blood vessels.
Amlodipine relieves angina symptoms by boosting blood flow to the heart.
In some instances, taking amlodipine may not make you feel any better. This does not imply that the medication is no longer effective, and you must continue to take it. It will probably take a few weeks for you to feel better if you’re taking amlodipine for angina. Until then, you’ll continue to experience spells of chest discomfort, and the symptoms may even worsen. Keep your angina treatment medication (spray or pills) with you at all times and use it if necessary.
Angina is a type of chest discomfort that occurs when not enough blood reaches the heart muscles. It generally occurs as a result of hardening and narrowing of the arteries leading to the heart.
Amlodipine expands the arteries, allowing more oxygen to reach the heart and preventing chest discomfort.
Note: Drug interactions might alter the way your drugs operate or put you at risk for significant adverse effects. This guide does not include every conceivable medication interaction. Maintain a list of all the items you use (including prescription and nonprescription medications, as well as herbal supplements) and discuss it with your doctor and pharmacist. Do not start, stop, or modify the dosage of any medications without first consulting your doctor. Check the labels of all your medications (such as cough and cold remedies, diet supplements, or NSAIDs like ibuprofen and naproxen) since they may include chemicals that raise your blood pressure. More information can be obtained from your pharmacist.
Interactions Between Drugs
Although certain drugs should never be used together, in other situations, two distinct medicines can be administered together even if an interaction occurs. In certain situations, your doctor may wish to adjust the dose or take additional measures. Your healthcare provider must know if you are taking any of the medications mentioned below while taking this drug. The interactions listed below were chosen for their potential relevance and are not meant to be exhaustive.
Using this drug in conjunction with any of the following medications is normally not advised, but may be necessary for some situations. If both medications are given simultaneously, your doctor may modify the dose or frequency with which you take one or both of them.
Combining this medicine in conjunction with any of the following medications may raise your chance of certain adverse effects, but using both treatments may be the best option for you. If both medications are given simultaneously, your doctor may modify the dose or frequency with which you take one or both of them.
Interactions with Other Drugs
Other medications, vitamins, or herbs you may be taking may interact with amlodipine oral tablets. When a chemical alters the way a drug functions, this is known as an interaction. This can be hazardous or impair the drug’s effectiveness.
Make sure your doctor is aware of any drugs, supplements, or herbs you’re using. To prevent drug interactions, your doctor should closely monitor all of your medications. Consult your doctor or pharmacist to learn how this medication may interact with other medications you’re getting.
Particular drugs should not be taken at or near the time of eating food, or when consuming certain types of food, since interactions may occur. Using alcohol or cigarettes in conjunction with some medications may also result in interactions. Discuss the use of your drug with food, drink, or cigarettes with your healthcare provider.
What are the positive effects of Amlodipine?
When used on a regular basis, amlodipine helps to relieve chest pain, but this does not cure the pain once it has started.
This could improve your capacity to exercise while also reducing the frequency of angina episodes. It should not be used to treat chest discomfort that occurs unexpectedly. As instructed by your doctor, use additional medicines (such as sublingual nitroglycerin) to alleviate chest pain incidents.
Amlodipine is a dihydropyridine calcium channel blocker that does not produce an increase in heart rate as a side effect. According to preliminary research, amlodipine does not worsen congestive heart failure. As a result, a randomized study was conducted in which 1153 patients with ejection fractions less than 30% were randomly allocated to receive amlodipine or placebo in addition to their standard treatment.
Amlodipine resulted in a 16% reduction in mortality. Mortality in individuals with nonischemic cardiomyopathy was reduced by 46%, but mortality in patients with ischemic cardiomyopathy remained constant. There was also a decrease in hospitalizations in the nonischemic cardiomyopathy group. This study was regarded as demonstrating that amlodipine is a potentially safe medication for the treatment of angina or hypertension in people with impaired left ventricular function.
Amlodipine is a vasoselective, inherently long-acting dihydropyridine calcium antagonist that selectively blocks calcium ion influx across cell membranes, having a higher impact on vascular smooth muscle cells than on cardiac muscle cells.
How amlodipine is used?
Your blood pressure should be regularly checked. Several formulations of this medicine’s liquid form must be shaken before using it, while others should not be shaken at all. You may check the manufacturer’s instructions or speak with your pharmacist for precise instructions.
To accurately assess the dose using a pressure measurement device/spoon. You cannot use an ordinary teaspoon because you may not get the correct dose.
Take the pills whole with a glass of water, before or after meals. If it’s simpler, dissolve the pills in a glass of water; but, if you do this, you must drink it all right immediately. It must be consumed every day all at the same time. And also Amlodipine can be taken with or without meals. While using this medication, avoid eating or drinking a lot of citrus or grapefruit juice. Grapefruit may raise the concentration of amlodipine in your body, causing adverse effects to intensify.
This medicine must be given on a regular basis if used to treat angina. When angina attacks occur, they should not be used to treat it. As recommended by your doctor, use additional medicines (such as sublingual nitroglycerin) to alleviate an angina episode. Consult your doctor or pharmacists for further details. Inform your doctor if your health does not improve or deteriorates (for example, your blood pressure readings remain high or increase, chest pain continues or worsens).
NOTE: Even though you feel perfect, continue to take amlodipine since you will still benefit from it.
When it comes to storing, keep the medication in a tightly sealed container at room temperature, away from heat, moisture, and direct light. Prevent the freezer from freezing.
Keep out of children’s reach.
Do not store out-of-date or no-longer-needed medications.
Consult with your doctor about how to effectively deal with any drugs you no longer need.
What is the recommended Amlodipine dosage?
The dosage of amlodipine is determined by the individual’s condition and how effectively their symptoms react to the therapy. When proposing a dosage, the doctor will also consider an individual’s age and medical history.
Amlodipine is available in tablet and capsule form, as well as 2.5 milligrams (mg), 5mg, and 10mg strengths, according to the FDA’s prescription information booklet.
Amlodipine is prescribed by doctors for a range of diseases, and the FDA recommends the following dosages:
For the treatment of high blood pressure:
Adults should begin with 5 mg once a day and work up to a maximum dosage of 10 mg daily.
2.5mg once a day for the elderly or those with liver issues.
2.5mg or 5 mg once a day for children aged 6–17 years.
The FDA also advises clinicians to modify a person’s dose based on blood pressure objectives but to wait between 7 and 14 days between adjustments.
For the cure of chronic angina or vasospastic angina, use the following medications:
Adults should take 5 to 10 mg once a day. Most patients will require 10 mg of the medication to properly treat their angina.
5 mg once a day for the elderly or those with liver issues.
For the treatment of chronic arterial disease:
Adults should take 5 to 10mg once a day.
5 mg once a day for the elderly or those with liver issues.
A doctor may deliver amlodipine as an intravenous injection or drip to those patients who have trouble swallowing, such as youngsters and the elderly.
Where can I get Amlodipine online?
Amlodipine is a prescription medicine at Truemedical. As a consequence, buying amlodipine online isn’t possible because the first step is to obtain a prescription from a registered medical professional. Furthermore, amlodipine OTC is not accessible for this reason.
Amlodipine may be purchased safely online from authentic pharmaceuticals. Before your purchase may be filled, you must already have an online consultation with a pharmacist treatment methods to connect with qualified medical professionals in their region and obtain an amlodipine besylate prescription, including amlodipine 5 mg and amlodipine 10 mg, as needed. The online consultation will guarantee that Amlodipine is the most appropriate medicine for your health condition.
Considerations before Taking Amlodipine
When determining whether or not to use a drug, the dangers must be balanced against the benefits. This is a decision that you and your physician will decide together. The following factors should be addressed before prescribing this medication:
Inform your doctor if you have ever experienced an unusual or adverse reaction to this or any other medications. Inform your doctor if you have any additional allergies, such as those to foods, colors, preservatives, or animals. When purchasing non-prescription medications, carefully read the label or package contents.
Appropriate investigations on the connection of age to the effects of amlodipine on blood pressure in children younger than 6 years old or on chest pain and discomfort have not been conducted. There is no evidence of safety or effectiveness.
Appropriate investigations conducted to now have not revealed any geriatric-specific issues that would restrict the use of amlodipine in the elderly. However, senior individuals are more prone to develop age-related renal, liver, or cardiac issues, which may necessitate care and a dose modification for those using this medication.
There have been no appropriate studies in women to determine baby risk when this drug is used while nursing. Before using this medicine during nursing, weigh the potential advantages against the potential dangers.
If you use amlodipine with other blood pressure medications, such as ramipril or lisinopril, the combination might occasionally cause your blood pressure to drop too low. You may feel dizzy or faint as a result of this. If this continues, inform your doctor, as your prescription may have to be adjusted.
If you’ve been taking this medication for a few weeks, don’t stop taking it all of a sudden. Stopping abruptly may cause your chest discomfort or high blood pressure to return or worsen. Consult your doctor about the best method to gradually lower the quantity you’re taking before quitting entirely.
After taking a dosage of this medication, you may have a brief headache. After you’ve been taking this drug for a while, this should become less obvious. Consult your doctor if this effect persists or if the headaches are severe.
Tenderness, swelling, or bleeding of the gums may occur in some individuals shortly after starting therapy with this medication. Brushing and flossing your teeth properly and on a regular basis, as well as massaging your gums, may help avoid this. See your dentist on a regular basis to get your teeth cleaned. If you have any concerns about how to care for your teeth and gums, or if you feel any soreness, swelling, or bleeding in your gums, consult your doctor or dentist.
Some medications can alter how amlodipine works. Before beginning amlodipine, talk with your doctor if you are on any of the following medications:
Antibiotics such as clarithromycin, erythromycin, or rifampicin blood pressure medications such as Diltiazem and verapamil
Antifungal medications Itraconazole or ketoconazole used to treat HIV or HCV (hepatitis C virus)
Drinking alcohol will drop your blood pressure further and may exacerbate some amlodipine adverse effects. Symptoms of high blood pressure are not always present. You may need to take blood pressure medicine for your entire life. Amlodipine is simply one component of a comprehensive treatment plan that may include diet, exercise, weight control, and other medicines. Maintain strict adherence to your food, medication, and exercise regimens.
Other medications should not be taken unless they have been discussed with your doctor. Prescription or nonprescription (over-the-counter [OTC]) medications for appetite control, asthma, colds, cough, hay fever, or sinus issues, as well as herbal or vitamin supplements, fall under this category.
Inform your doctor about any additional heart or blood pressure drugs you are currently taking.
When you initially start taking amlodipine or when your dose is raised, your chest discomfort may worsen. Call your doctor right away.
Even if you feel OK, remain taking amlodipine if you are being treated for high blood pressure. Symptoms of high blood pressure are often absent. It’s possible that you’ll have to take blood pressure medicine for the rest of your life.
Amlodipine is merely one component of a comprehensive treatment plan that may include diet, exercise, weight management, and other drugs. Keep a close eye on your nutrition, medicine, and exercise routines.
IMPORTANT: Amlodipine is not recommended for children under the age of six (6).
Typical adverse reactions/Side Effects
Amlodipine, like other medications, can have adverse effects, but not everyone experiences them.
As your body becomes used to the medication, the side effects usually improve.
Common Side Effect
These frequent side effects affect more than one out of every 100 persons. They are typically mild and brief. If the adverse effects affect you or persist for more than a few days, see your doctor or pharmacist:
- feeling dizzy flushed with a thumping pulse
- ankle swelling
Severe side effects
If you encounter any of the following symptoms, see a doctor immediately.
stomach issues – intense pain in your stomach, with or without bloody diarrhea, feeling ill, and being sick (nausea and vomiting) can all be indications of pancreatitis yellow skin, or when the whites of your eyes become yellow – this might be a symptom of liver trouble
Chest pain that is new or severe – this should be investigated since chest discomfort is a probable indication of a heart attack.
IMPORTANT: These aren’t all the side effects of amlodipine. See the booklet within the medication packaging for a complete list.
Other Rare Side Effects:
- Black, tarry stools are quite rare.
- gums that bleed
- scorching, peeling, or skin loosening
- There is blood in the urine or feces.
- vision issue
- Feelings of burning, crawling, itching, numbness, prickling, “pins and needles,” or tingling
- pain or discomfort in the chest
- skin that is chilly and clammy
- sweating cold sweats
- urine that is a dark golden color
- neck veins dilated
- dizziness or lightheadedness while rising from a seated or lying posture
- additional heartbeats
- severe exhaustion
What should be done about side effects?
If you have a headache, make sure you relax and drink lots of water. Don’t overdo it on the booze. Request a pain reliever from your pharmacist. Headaches should often subside after the first week of using amlodipine. If they continue for more than a week or are severe, consult your doctor.
Feeling dizzy – if amlodipine causes dizziness, stop what you’re doing and rest or lie down until you feel better.
Flushing – consider reducing your intake of coffee, tea, and alcohol. It may be beneficial to keep the room chilly and to use a fan. You may also spray chilly water on your face or drink cold or iced drinks. After a few days, the flushing should stop. Contact your doctor if it doesn’t go away or is causing you difficulties.
A hammering heartbeat – if this occurs on a regular basis after taking your medication, consider taking amlodipine when you can sit down (or lie down) when the symptoms are at their worst. It may be beneficial to limit alcohol, smoking, caffeine, and large meals, as they may exacerbate the condition. If you are still experiencing issues after a week, consult your doctor as you may require a new type of medication.
Swollen ankles – elevate your legs when sitting.
What if I forget to take a dose?
As shortly as you realize, take the missed dosage. Skip the missing dosage if you are more than 12 hours late. Do not take more pills to make up for a missing dosage.
What to refrain from?
If you rise too quickly from a sitting or sleeping posture, you may feel dizzy. To avoid a fall, get up slowly and steadily.
Are there any medications that are comparable to amlodipine?
There are numerous calcium channel blockers that operate similarly to amlodipine.
Nifedipine, felodipine, lacidipine, and lercanidipine are among them. Other calcium channel blockers, such as diltiazem and verapamil, have different cardiac effects.
There are a variety of different medications available to help you reduce your blood pressure or manage chest discomfort.
They function differently than calcium channel blockers and include:
ACE inhibitors, such as ramipril and lisinopril, angiotensin receptor blockers, such as candesartan, beta-blockers, such as bisoprolol pills that cause you to pee more (diuretics), such as bendroflumethiazide
If you are unable to use amlodipine or other calcium channel blockers due to adverse effects, you may be able to switch to another blood pressure medication.
Based on age, gender, and medical history, your doctor will advise you on which one would be ideal for you.
What happens if I don’t take it anymore?
If you wish to discontinue taking amlodipine, consult your doctor.
Stopping amlodipine may cause your blood pressure to rise, increasing your chance of having a heart attack or stroke.
If you are troubled by side effects, your doctor may be able to recommend an alternative medication.
In the event of an emergency or overdose
In case of an overdose, immediately call for medical help. If the sufferer has collapsed, had a seizure, is having difficulty breathing, or cannot be roused, contact 911 immediately.